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Tryponil RTU



Solution for parenteral administration


Diminazene aceturate belongs to the group of aromatic diamidines, and has activity against trypanosomiasis, babesiosis, theileriosis and mixed haemoprotozoan infections.


Tryponil RTU is indicated for the therapeutic treatment and prophylaxis of trypanosomiasis, babesiosis, mixed haemoprotozoan infections and theileriosis in cattle, buffalos, sheep, goats, horses and dogs.


1. Trypanosomiasis:      T. congolense, T. vivax , T. brucei and T.evansi

2. Babesiosis:               B. bovis, B. bigemina, B. ovis, B. motasi, B. canis, B.equi and other Babesia spp.

3. Mixed infections:       Mixed infections of Trypanosoma and Babesia spp.

4. Theileriosis:               Theileria annulata


Tryponil RTU offers prophylactic protection against Asiatic (European) Redwater (B. bovis) for 2 weeks, and African Redwater (B. bigemina) for 4 weeks. It can be used as a short-term control in outbreaks with a high morbidity rate. Treatment of all affected and exposed cattle will bring about rapid but temporary relief.

Contra indications

• Administration to animals with known hypersensitivity to diminazene and/or phenazone
• Administration to animals with an impaired renal and/or hepatic function
• Administration of the product to camels

Side effects

After overdosing or repeated dosing, toxic disturbances of the central nervous system may develop (salivation, sweating, tremors). In rare cases, multiple therapeutic doses can produce severe nervous signs and prominent haemorrhagic and malacic lesions of the cerebellum and thalamus in cattle and dogs.

After multiple therapeutic doses, degenerative fatty changes can occur in liver, kidneys, myocardium and muscles.


For deep intramuscular administration.


The usual therapeutic dose is 1 ml per 20 kg body weight (3.5 mg/kg). For infections with T. brucei, T. evansi and Theileria annulata, this dose should be doubled (1 ml per 10 kg). For infections due to resistant strains, the dose may be increased to 8 mg/kg body weight (1 ml per 8.75 kg). Do not exceed a total dose of 4 g (57 ml) per animal. When large quantities of Tryponil RTU solution are administered, it is advisable to divide the amount to be injected over multiple sites in order to avoid local pain reactions.

Withdrawal times

– For meat      : 20 days.

– For milk       :   3 days.


Dogs must be injected only once, and strictly according to body weight at 0.1 ml per 2 kg. The prescribed dose should not be exceeded or repeated under any circumstances.

The use of Tryponil RTU will render prophylactic protection for 2-4 weeks as mentioned above. Injecting all cattle with Tryponil RTU at the recommended dosage should stop further cases of Redwater within 24 hours, and cure affected animals if not terminally ill. Keeping the animals tick free reduces chances of Redwater transmission. The control of ticks on cattle should therefore be coupled to the process.

If a bovine should be treated for Redwater with Tryponil RTU, the animal should not be vaccinated against Asiatic (European) Redwater for 1 month, and against African Redwater for 2 months after treatment. If Tryponil RTU has been used to suppress a Redwater vaccine reaction, revaccination of the treated animals is necessary. If immunity to Asiatic (European) Redwater is required, revaccination after 1 month is recommended. If immunity to African Redwater is required, revaccination after 2 months is recommended.

Avoid direct skin contact with the therapeutic solution. Wear protective gloves and clothing to avoid staining. Divide the volume to be injected over two or more separate sites in case of emaciated and/or debilitated animals, and avoid underdosing by a careful estimation of the target animal’s body weight.

Discard all empty containers and injection equipment according to local waste disposal regulations.

Although this remedy has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.


Vial of 50 and 100 ml.
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