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Colexil Oral



Solution for oral administration


The combination of colistin and enrofloxacin acts additive. Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics. Enrofloxacin is active against Gram-negative and Gram-positive bacteria and mycoplasmas. It is well absorbed after oral administration and rapidly excreted in the bile and urine, mostly as enrofloxacin and the metabolite ciprofloxacin. Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. It is absorbed poorly after oral administration and serum concentrations are generally undetectable in target species. Orally administered colistin is eliminated almost totally in faeces.


Colexil Oral is indicated for gastrointestinal, respiratory and urinary tract infections caused by colistin and enrofloxacin sensitive micro-organisms like Campylobacter, E. coli, Haemophilus, Mycoplasma, Pasteurella and Salmonella spp. in poultry and swine.

Contra indications

Hypersensitivity to colistin and/or enrofloxacin or to any of the excipients.
Administration to animals with seriously impaired renal and/or hepatic functions.
Cases of resistance against quinolones and/or colistin.
Administration to poultry producing eggs for human consumption.
Administration to pregnant or lactating animals.
Administration of Colexil Oral in subtherapeutic doses or for prevention.

Side effects

All members of the quinolone family of antibiotics have the ability to cause articular lesions in young animals.
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases, mild diarrhoea or vommiting.
Side-effects for quinolones like rash and central nervous system disturbance may occur.
During a period of rapid growth, enrofloxacin may affect joint cartilage.


For oral administration:


1 litre per 2000 litres of drinking water for 3 – 5 days.


1 litre per 3000 litres of drinking water for 3 – 5 days.


Only sufficient medicated drinking water should be prepared to cover daily requirements. Medicated drinking water should be replaced every 24 hours.

Withdrawal times

– For meat and offal: 9 days.


Bottle of 1000 ml.
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