Solution for parenteral administration
Closantel is a synthetic anti parasitic agent which is highly effective against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Closantel decouples the mitochondrial oxidative phosphorylation, which leads to the inhibition of ATP synthesis. That causes a significant change in the energy metabolism, and as a consequence the death of the parasite.
Treatment and prevention of several infections caused by parasites sensitive for closantel like Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.
In cattle: treatment and prevention of infections caused by parasites sensitive for closantel like Hypoderma bovis.
In sheep: treatment and prevention of infections caused by parasites sensitive for closantel like Paramphistomum spp, Chabertia ovina and Oestrus ovis.
Hypersensitivity to closantel.
Do not use for intravenous or intramuscular administration.
Do not use in cattle or ewes producing milk for human consumption, including in the dry period.
Do not use in the last trimester of pregnancy in heifers, which are intended to produce milk for human consumption.
Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.
Hyper acute anaphylactic reactions in cattle.
Overdoses can cause reduced visibility or blindness, anorexia, lack of coordination and general weakness.
For subcutaneous administration:
Sheep, cattle less than 200 kg : 1 ml per 10 kg body weight
Cattle of 200 to 400 kg : 20 ml
Cattle over 400 kg : 20 ml plus 5 ml per 100 kg of extra body weight
Do not administer more than 20 ml in cattle per injection site.
– For meat: 77 days.